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Participants were randomly assigned to receive either semaglutide (0.25 mg/week for 4 weeks, 0.5 mg/week for 4 weeks, and 1.0 mg for 1 week) or placebo over nine weeks of outpatient treatment
A few important notes about titration
Comorbidities such as heart failure and cardiovascular disease, prevalent in individuals with CKD and diabetes, increase the risk for hyperkalemia, usually due to associated medications
Semaglutide works by mimicking the GLP-1 hormone, slowing gastric emptying, stimulating insulin secretion, and lowering glucagon levels
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