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For instance, one study from the journal Frontiers in Medicine found that people with psoriasis had significantly lower levels of glutathione

The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

In animal models, this preservation was associated with increased fat oxidation relative to storage

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