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In a separate meta-analysis, a significantly increased risk of cholelithiasis (OR 1.30
Updated Phase 3 data from December 2025 (TRIUMPH-4 trial) pushed those numbers even higher, with the 12mg dose delivering 28.7% weight loss at 68 weeks, which works out to approximately 71 lb lost on average
In vitro studies have reported inhibition of several markers of endothelial dysfunction after exposure of human vascular endothelial cells to liraglutide [30, 31]
(2) The second reason that the increase of use is alarming is because of effects on patients access to their prescribed drugs
![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
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