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Heavy drinkers metabolize alcohol faster through MEOS induction and CYP2E1 upregulation, but this increased clearance speed does not reduce impairment or protect the liver

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Oncogenic alterations [10, 18,19,20,21] reshape lipid metabolic pathways at the transcriptional and posttranscriptional levels, while microenvironmental cues, such as growth factors, nutrient availability, and metabolic stresses, such as hypoxia further sculpt this metabolic network

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