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Nausea affected up to about 29 percent of participants Diarrhea up to about 23 percent Vomiting up to about 13 percent in some studies Reports of sleep disturbance or insomnia were not prominent in the trial safety tables for Zepbound

Osteoporosis International, 18(10), 1319-1328

As with the other peptides weve discussed so far, these effects are more common upon the initiation of therapy

Given these differences, selecting the right GLP-1RA should be based on individual patient needs, including glycemic targets, weight loss goals, tolerability, and preference for dosing frequency