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Notably, EV-associated DAMPs have been found in stored red blood concentrates [238], suggesting that eryptosis-mediated generation of EVs might exert immunomodulatory DAMP-triggered effects

The ferroptosis activator RSL-3 and the PI3K/Akt pathway inhibitor LY294002 reversed Neuritins inhibitory effect on ferroptosis, indicating that Neuritin suppresses neuronal ferroptosis via PI3K/Akt pathway activation (Song et al., 2025)

Tramutola A, Arena A, Cini C, Butterfield DA, Barone E

The follicular reserve established at birth is finite, and a progressive decline in follicle numbers is a hallmark of diminished reproductive capacity (Meng et al., 2018)