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El GLP-1 ha servido de desarrollo de toda una familia farmacolgica (los arGLP-1), mientras que el GIP no ha conducido a un desarrollo similar, probablemente porque sus efectos insulinotrpicos estn alterados en las personas con DM2, a pesar de que los efectos insulinotrpicos del GIP pueden ser restaurados tras 4 semanas de normalizacin de la hiperglucemia con insulina en pacientes con DM2
During significant caloric restriction, ensuring adequate dietary protein (at minimum 1.2 to 1.6 grams per kilogram of body weight) supports muscle preservation and complements the favorable body composition changes these medications produce
the results also demonstrated that these doses led to significant reductions in body weight
