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This would be in line with preclinical observations that incretin receptor expression is down-regulated by exposure to high glucose, and improves once normoglycaemia is restored (48), and that dys-regulation of glycaemic control in otherwise healthy humans leads to impaired incretin actions (49)

pH 7.39, osmolarity 320 mOsm) with 10 nM ghrelin or 10 nM GLP-1

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