semaglutide vs tirzepatide mechanism of action for Weight Loss: Which Drug Delivers Better Results? Study reveals distinct mechanisms of – Semaglutide vs Tirzepatide: One Clear

High levels of body fat especially visceral fat surrounding internal organs increase the likelihood of insulin resistance and type 2 diabetes and contribute to hypertension, high cholesterol and an increased risk of cardiovascular diseases such as heart attack and stroke

GLP-1 drugs are also not advised during breastfeeding, as safety data for infants currently remains insufficient

Mechanisms identified include: increased cardiac utilization of ketones increased autophagy (recycling of intracellular components)l decreased inflammation & oxidative stress improved mitochondrial function decreased intracellular Ca & Na overload decreased fibrosis improved myocardial diastolic function decrease myocardial hypertrophy Figure: Mechanism of action of action of SGLT-2 inhibitors in the kidney

Research suggests it can be effective over time