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19 Mechanistically, this vesicular cargo acts through the glutamine-fructose-6-phosphate transaminase 1 (GFPT1)-hexosamine biosynthesis pathway and transcriptional regulator BTB and CNC homolog 2 (BACH2)-dependent repression of the SLC7A11-GPX4 axis, thereby lowering the ferroptotic threshold of adjacent cells

Its a way to shape a receptor-mediated event

Cell lines and culture conditions LLC/1 (Lewis Lung Carcinoma) and B16-F10 (Melanoma) cell lines were cultured following the American Type Culture Collection ( recommendations and standard methods

Inhibition of residual homologous recombination further enhances the sensitivity to IGF-IR inhibitors [95]