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Semaglutide: Well-characterized GI side effect profile over 7+ years

[6] Proposed mechanisms for cardiovascular benefits of incretin-based therapies include: Vascular effects : Improved endothelial function and reduced arterial stiffness Anti-inflammatory actions : Decreased systemic inflammation and oxidative stress Metabolic improvements : Enhanced insulin sensitivity and reduced hepatic glucose production Hemodynamic changes : Blood pressure reduction, though with modest increases in heart rate Renal protection : Reduced albuminuria and preservation of kidney function The cardiovascular benefits appear partially independent of weight loss itself, suggesting potential cardioprotective properties of incretin pathway activation

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Generally well tolerated