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6) from Gipr fl/fl , Gipr Syn/ , Glp1r fl/fl and Glp1r Wnt1/ mice treated with either vehicle or mGIPR-Ab/P1

Upstream processing Solid-phase peptide synthesis (SPPS) The GLP-1 manufacturing process starts with peptide synthesis, during which amino acids are attached one at a time to form a peptide chain

Symptoms Heavy or prolonged menstrual bleeding Pelvic pain or pressure Frequent urination (if pressing on bladder) Constipation (if pressing on bowel) Pain during intercourse Infertility or miscarriage (less common) Some fibroids are asymptomatic and discovered incidentally