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It is a nonspecific and uncontrolled process in which the resulting reactive oxygen species readily react with surrounding molecules, leading to intensification of the process, and the damage of the cell membrane

They are generally used in cycles with scheduled breaks, often several weeks on followed by time off, to reduce the risk of the pituitary becoming less responsive

Less commonly, injection site reactions can be larger and more widespread

This improved ability to control intracellular mycobacteria could be through the improved redox homeostasis in the cell and possibly through modulation of cytokines that result in a more effective immune response against these infections