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The results were highly encouraging

observed a high frequency of promoter hypermethylation and progressive loss of GPx3 expression in Barretts esophagus and its associated lesions, and these authors also confirmed the known function of GPx3 as a potent antioxidant [54]

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Hence, one of the questions that remains to be clearly answered is whether the reported GSH decrease in IBD is an epiphenomenon of colitis or if GSH depletion plays any pathophysiological role in the development of colitis