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And when that happens, a lot of people will see that initial weight loss in their face first." This rapid loss of facial fat can lead to sunken cheeks and temples, making the bones of the face appear more prominent. Additionally, the skin may lose elasticity and sag, accentuating existing wrinkles and fine lines
Insulin sensitivity and metabolic flexibility Both compounds improve insulin sensitivity, but through different mechanisms
Managing these factors may help support healthy antioxidant defenses and overall wellness
Notably, the same meta-analysis highlighted that liraglutide, particularly when compared to higher doses of semaglutide or tirzepatide, promoted weight loss without a clinically meaningful reduction in lean mass [77]
