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Metoclopramide also interacts with anticholinergic drugs (antagonistic effects on gastric motility), opioids (additive CNS depression), and antipsychotics (additive extrapyramidal risk)
Studies have shown that elderly people have favourable safety profiles (Karagiannis et al
Furthermore, a RCT (NCT03357380) is currently comparing the change in early stages of scar tissue as well as fat deposition in the liver, as detected by magnetic resonance imaging scans, in patients treated with semaglutide or placebo for 72 weeks
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