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A Danish nationwide cohort study also reported a lower risk of corticosteroid use and hospitalization in IBD patients with DM2 undergoing GLP-1 RAs rather than other antidiabetic treatments (98)

481,482 (4) A fourth targeted drug approach is the activation of PPAR- in mature adipocytes that then induces altered expression of several genes (increased GLUT4 and adiponectin expression, along with decreased TNF-, IL-6 and leptin expression) involved in the insulin signaling cascade, thereby improving insulin sensitivity

Mice were then given daily subcutaneous (SQ) injections of semaglutide (12 g/kg) for 14 days and changes in bodyweight and food intake were recorded (Fig

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