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Following intraperitoneal administration in rat models, BPC-157 increased serotonin synthesis in the substantia nigra reticulate and medial anterior olfactory nucleus

This explains anecdotal success with: Sciatic nerve recovery Post-surgical nerve pain Numbness, tingling, or radiating nerve issues from disc injury BPC-157 promoted peripheral nerve regeneration and protected against neuroinflammation-induced degeneration via modulation of IL-6 and NGF expression. Miklic et al., Neuroscience Letters 5

The lyophilized powder is stable as shipped

When applied topically in a properly formulated serum, GHK-Cu penetrates into the living layers of the skin where it activates a cascade of biological responses: Stimulates fibroblasts to produce collagen I, III, and VI the primary structural proteins of the dermis Activates TGF- the growth factor that signals tissue remodeling and regeneration Inhibits MMP enzymes that break down existing collagen and elastin Upregulates antioxidant enzymes including superoxide dismutase and catalase Modulates over 4,000 genes activating those associated with regeneration and suppressing those associated with inflammation and aging Stimulates proteoglycans including decorin, which regulates collagen fiber organization and gives skin its structured appearance Most skincare peptides work on a single pathway signal peptides stimulate collagen, neurotransmitter peptides relax muscles