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There are theoretical off-ramps, but none have been tested. Mellor can describe what a well-designed trial might look like: A step-down protocol using lower doses, a transition through oral semaglutide or tirzepatide and/or a bridge using total diet replacement with food reintroduction and behavioral retraining
This metabolic convergence is reflected, in clinical studies, by a body weight reduction of up to 24% in 48 weeks (Phase 2 data, NEJM 2023)
Accountability and Support Weight loss is as much behavioral as it is biological
Liraglutide is equipotent to GLP-1 in activating GLP-1R, with an EC50 of 61 pM for liraglutide vs
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