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Comparable effects have been observed in mouse oocytes exposed to antimony (Sb) [92], porcine oocytes exposed to cadmium (Cd) [93], and methylmercury chloride (MMC) [28], and in the presence of phenanthrene (PHE) [30], which additionally perturbs calcium homeostasis

Among these systems, glutathione (GSH) peroxidase 4 (GPX4) plays a dominant role by converting LOOH into nontoxic lipid alcohols (LOH) using GSH as an electron donor 10

Using them in combination provides a more comprehensive and balanced approach to your well-being