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Pancreatitis Risk There is a rare but serious risk of pancreatitis
Deamidation Asparagine residues in peptides spontaneously convert to aspartate through a deamidation reaction, particularly at elevated temperatures and at neutral to basic pH
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The recommended approach is to discontinue semaglutide, allow a washout period of at least 2-3 weeks (given semaglutide approximately one-week half-life), and then begin retatrutide titration from the standard 1 mg starting dose
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