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Consistently, AMPK activation mediates the protective effects of glucagon-like peptide-1 receptor agonists and the Tangshenning formula against TEC ferroptosis and DKD progression (197, 198)
Possible side effects are not well defined because no controlled human safety trial exists
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Future research should focus on large-scale, well-controlled randomized trials with standardized dosing protocols, clearly defined deficiency thresholds, and long-term follow-up to strengthen the evidence base and guide clinical practice
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