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Animal studies show significant improvements in body composition, metabolic markers, and muscle function with minimal adverse effects
Benefits are often greatest in individuals with existing B12 deficiency or suboptimal methylation
[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations
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