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Nuclear gene expression reprogramming: metabolism, antioxidation and mitochondrial biosynthesis Mitochondria serve not only as energy hubs but also as sources of diverse metabolic signals that modulate nuclear gene transcription and translation via retrograde signaling, coordinating metabolism and transcription [228]

( 6 ) Many patients also report reduced cravings for high-calorie, high-sugar foods, making it easier to maintain a calorie deficit

Moreover, further work is needed to directly quantify sulfur species in tissues, decipher the specific transcriptional regulation of SQOR, and determine whether these regulatory mechanisms are universal across different diseases

Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular development, with higher secretion levels associated with successful implantation and pregnancy establishment [59, 420]