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These effects have been confirmed in animal experiments, but not in humans, and the specific mechanism remains unknown

This gap between expectations and reality is one of the leading drivers of negative reviews

Clinical trials reveal that 10-15% of participants taking GLP-1 medications like Wegovy or Mounjaro qualify as non-responders, losing less than 5% of their body weight

However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10