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Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose

They may also indirectly help with blood pressure regulation, though they are not yet FDA-approved for this purpose

the recommended duration between discontinuation of the GLP-1 agonist prior to a planned pregnancy

They can reduce the risk of second heart attacks and strokes, and some studies show they help with conditions like sleep apnea