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Methylcobalamin is the bioactive form of vitamin B12, meaning it doesn't require the liver conversion step
There is insufficient evidence for the use of B12, beyond correction of deficiency, in cognitive impairment, depression and fatigue
Common side effects: Gastrointestinal (nausea, diarrhea, vomiting, constipation) typically mildtomoderate and dosedependent
There are rare case reports linking high-dose B12 supplementation to acne flares, possibly through effects on skin bacteria that produce inflammatory compounds
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