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These changes, which are critical for the maintenance of functional capacity, are mediated by a complex array of metabolic and biochemical processes, including altered muscle metabolism related to declining anabolic hormones with age, elevated myostatin levels, changes in myokine and adipokine profiles, and inflammation [4]

These processes include chromosomal maintenance, oxidative balance, and neuroendocrine signaling pathways

Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R: Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities