Capitalizing on this understanding, nutritional interventions target OA through a multi-tiered approach: (1) Upstream regulation using anti-inflammatory nutrients (e.g., omega-3 fatty acids, polyphenols) to quell systemic inflammation and oxidative stress (10)
Vitamin C regenerates oxidized glutathione back to its active form, supports collagen synthesis, suppresses excess melanin formation, and enhances overall antioxidant capacity
This conceptual integration is especially relevant in PD, in which hallmark features of oxytosis/ferroptosis including oxidative stress, iron accumulation, and glutathione depletionare prominently observed (Lewerenz et al., 2018)
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