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Step 1: Identify Normal Anion Gap Metabolic Acidosis Step 2: Calculate Urine Anion Gap (UAG) UAG = Urine Na + Urine K Urine Cl Negative UAG: Kidney acid excretion is intact think diarrhea or gastrointestinal bicarbonate loss Positive UAG: Defective renal acid excretion suggests RTA Types of Renal Tubular Acidosis 1 Type 1 (Distal RTA) Defect: Failure of distal nephron -intercalated cells to secrete H

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In RA and AxSpA patients, low disease activity or remission induced by biologic disease modifying anti-rheumatic drugs (bDMARDs), mainly anti-TNFs, resulted in stabilization of subclinical atherosclerosis [57, 58], while a meta-analysis shows amelioration of atherosclerosis and arterial stiffness in anti-TNF--treated patients with inflammatory arthritis (RA, PsA, AxSpA) [59]

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