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Importantly, low-dose PT-141 effectively prevented weight regain after discontinuation of tirzepatide therapy, a major challenge in obesity management with GLP-1/GIP medications

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Hypoxia and cellular metabolism in tumour pathophysiology

Although several preclinical anti-cancer outcomes have been achieved, such as with ferroptosis inducers, translating oxidative cell death mechanisms into effective clinical therapies requires rigorous testing, including assessments of bioavailability, toxicity, and off-target effects