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The European Medicines Agency's Pharmacovigilance Risk Assessment Committee (PRAC) concluded in April 2024 that there is no causal association between GLP-1 receptor agonists and suicidal or self-injurious thoughts, though monitoring continues

Table of Contents How Retatrutide Affects Heart Rate Retatrutide increases resting heart rate primarily through GLP-1 receptor-mediated chronotropic effects at the sinoatrial node, potentially amplified by its glucagon receptor agonism, which independently raises heart rate and cardiac contractility

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