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For metabolism of NR, NRK1 is expressed in most tissues but is absent in the spleen and white adipose tissue, while NRK2 is only present in skeletal muscle, heart, and white adipose tissue (WAT) 40
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Additionally, under stress or disease conditions, such as hypoxia, cellular senescence can be induced
[19] These licensed treatments offer a far safer, evidence-based alternative to unlicensed investigational compounds
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