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As the primary hormonal mediator of circadian night, melatonin plays a pivotal role in stabilizing sleepwake rhythms and synchronizing central and peripheral clocks
Its non-selectivity, considered a clinical drawback, is a scientific advantage: it allows for the isolation of the relative contributions of each MCR subtype using selective antagonism protocols (HS024, JNJ-10229570, MCL-0129)
PARP Reduction PARP, or poly ADP-ribose polymerase, is a protein involved in DNA repair
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