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The first conjugation event involves the covalent attachment of Atg12 to Atg5, which requires Atg7 and Atg10 acting as E1 and E2-like enzymes, respectively
These agents exhibit excellent overall safety profiles, with only a few mild adverse reactions observed
Healthcare law firms analyzing the question conclude that a salt-form change does not create meaningful legal differentiation under the "essentially a copy" doctrine, the same reasoning the FDA uses to prevent minor modifications from circumventing drug regulations
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