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Research demonstrates that BPC-157 upregulates vascular endothelial growth factor receptor-2 (VEGFR2) at both mRNA and protein levels in endothelial cells without increasing VEGF-A itself, instead sensitizing cells to existing VEGF signaling while simultaneously activating the Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway

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In addition, different therapeutic windows, treatment durations, and dosing regimens should be investigated to better clarify the influence of sex and developmental timing on treatment efficacy in ASD models