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2 However, it is not a treatment strategy for cognitive decline, cognitive impairment, or dementia
Since their initial approval in the early 2000 s, the pharmacotherapy of GLP-1 RAs has been well recognized not only for achieving glycemic targets but also for their effectiveness in promoting satiety and weight loss, as well as their association with reductions in cardiovascular risk and all-cause mortality
The trade-off is a very short half-life of approximately 20-30 minutes after subcutaneous injection, making it unsuitable for systemic use and largely studied in local tissue applications [10]
doi: 10.1016/j.addr.2023.114775 78 LongT
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