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directly delivered purified proteasomes into cells through mesoporous silica nanoparticle-mediated endocytosis, and they found that extraproteasomal transfer reduces tau aggregates and promotes cell survival against tau-induced proteotoxic stress (Han et al., 2014)

Ubiquitin stability and the lys 63-linked polyubiquitination site are compromised on copper binding

By delivering powerful antioxidants directly into the bloodstream, this treatment allows the body to absorb nutrients more efficiently than oral supplements

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