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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

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A marked induction of GST isoenzymes could contribute to a strong and possibly early symptomless type of resistance, while a less increase or a decrease of GST activity may confer only a weak virus resistance that eventually results in susceptibility (Gullner et al., 1995b)

10.1007/s00125-023-05973-w 78 SoresiM.GiannitrapaniL