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4b), including Cyp8b1 which belongs to the primary BA synthetic pathway

Although GLP-1RAs are known to have action in the brain, it is possible one mechanism by which GLP-1RAs reduce consumption of ingested drugs such as alcohol is, at least in part, through peripheral mechanisms

Because they slow digestion and suppress appetite, your body can become: Dehydrated or constipated due to sluggish digestion Undernourished from eating less food (and fewer nutrients) Fatigued from protein or calorie deficits Losing lean muscle instead of just fat Experiencing gut microbiome disruption Craving sugar or carbs due to blood sugar dips Meet your new GLP-1 sidekicks: our GLP-1 Support Supplements

Previous rodent studies demonstrated that GLP-1 receptor agonists suppressed the rewarding effects of alcohol and reduced alcohol consumption