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The anabolic variety and redox status of GSH in the myocardium under pathological conditions When the heart is under stress from pathological factors, GSH redox homeostasis is disrupted, which is manifested by a significant decrease in GSH content and accumulation of GSSG in the myocardium
Additionally, changes in the response to iron ion pathway might affect the antioxidant capacity of cells, particularly the activity of GPX4, thereby reducing cellular antioxidant defense [59]
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