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Endocrinology 144 , 37993810 (2003)
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Obviously this ignores all those who require life long treatment due to other causes of B12 deficiency (of which there are many), thereby potentially causing great harm to the vast majority of their B12 deficient patients
As noted above, the mid-region residues (S19 Cagri- P25 Cagri ) form the prototypical bypass motif that was observed for rAmy/San385, constrained by conserved intramolecular hydrogen bonds between the backbone of L16 Cagri /F23 Cagri and S20 Cagri , and the backbone of P25 Cagri and N21 Cagri (Fig
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