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The higher doses and costs are justified by accelerated timelines in appropriate contexts
in the latter, proopiomelanocortin (POMC) neurons are present and it is believed that endogenous GLP-1 induces satiety, affecting both anorexigenic and orexigenic signaling pathways
Thus, following the example of cancer, drug therapy could precede bariatric surgery in order to render it safer and more feasible, but could also follow if the results are not satisfactory
They are particularly valuable for patients with established cardiovascular disease, heart failure, or chronic kidney disease
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