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What an integrated report can justify at present is stratification and trial-ready phenotyping with appropriate counselling, not a treatment prescription, because endotypes are not automatically therapeutically tractable without prospective evidence of benefit from biomarker-guided care [5, 291, 474]

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Semaglutide 24 mg once a week in adults with overweight or obesity (STEP programme)

This includes eligibility screening, dose titration, a critical phase in tirzepatide therapy where doses advance from the 2.5 mg starting dose through escalating levels (5 mg, 7.5 mg, 10 mg, and 12.5 mg or 15 mg), and ongoing monitoring of metabolic and clinical outcomes